Circadian Redox and Metabolic Oscillations in Mammalian Systems
نویسندگان
چکیده
منابع مشابه
Redox and Metabolic Oscillations in the Clockwork
Daily (circadian) clocks have evolved to coordinate behaviour and physiology around the 24-h day. Most models of the eukaryotic circadian oscillator have focused principally on transcription/translation feedback loop (TTFL) mechanisms, with accessory cytosolic loops that connect them to cellular physiology. Recent work, however, questions the absolute necessity of transcription-based oscillator...
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AIMS Circadian rhythms permeate all levels of biology to temporally regulate cell and whole-body physiology, although the cell-autonomous mechanism that confers ∼24-h periodicity is incompletely understood. Reports describing circadian oscillations of over-oxidized peroxiredoxin abundance have suggested that redox signaling plays an important role in the timekeeping mechanism. Here, we tested t...
متن کاملSystems biology of mammalian circadian clocks.
Systems biology is a natural extension of molecular biology; it can be defined as biology after identification of key gene(s). Systems-biological research is a multistage process beginning with (a) the comprehensive identification and (b) quantitative analysis of individual system components and their networked interactions, which lead to the ability to (c) control existing systems toward the d...
متن کاملMetabolic Control Mechanisms in Mammalian Systems
1. The ability of exogenously administered cyclic AMP (adenosine 3': 5'-monophosphate) to exert andromimetic action on certain carbohydrate-metabolizing enzymes was investigated in the rat prostate gland and seminal vesicles. 2. Cyclic AMP, when injected concurrently with theophylline, produced marked increases in hexokinase, phosphofructokinase, glyceraldehyde phosphate dehydrogenase, pyruvate...
متن کاملCircadian oscillations of protein-coding and regulatory RNAs in a highly dynamic mammalian liver epigenome.
In the mouse liver, circadian transcriptional rhythms are necessary for metabolic homeostasis. Whether dynamic epigenomic modifications are associated with transcript oscillations has not been systematically investigated. We found that several antisense RNA, lincRNA, and microRNA transcripts also showed circadian oscillations in adult mouse livers. Robust transcript oscillations often correlate...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2014
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2013.5582